This in-depth manual was initially developed in response to a critical need to support clinicians in remote and rural communities in Central Australia. Over time its use has extended to be used across other areas in remote Australia. The Manual supports clinicians who may not have remote-specific training but are expected to provide a wide range of clinical services in an unfamiliar and often challenging environment. The protocols cover ‘what to do’ in remote settings for conditions that are common, high risk, unfamiliar, or dangerous, have important public health implications and need coordinated, standardised care.