The National Rural and Remote Nursing Generalist Framework 2023 –2027 (the Framework) describes the unique context of practice and core capabilities for rural and remote Registered Nurses in Australia. It was developed and led by an expert steering committee of nursing peak body representative including CRANAplus. The Framework through domains and capabilities contextualises the comprehensive skill set necessary for nurses to work to their full scope of practice as rural and remote nursing generalists. Culturally Safe care in partnership with families, communities and multidisciplinary colleagues is intrinsic to the Framework.